Bring on the moodiness and the headaches... Thank you Lupron! I have had a dull headache over the past few days, but the Moodiness just struck me yesterday afternoon... I feel cranky and just overall not in the best mood...I dislike the mood changing side effects that the Lupron bring on. Thankfully I am off work for a few days. It takes a lot of energy to be happy all day at work.